Genetics of the complement system.
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چکیده
منابع مشابه
Genetics of the complement system.
The complement system, unlike the coagulation system, was largely characterized by in-vitro techniques which did not make use of genetically deficient plasmas. The existence of the genetically deficient plasmas. The existence of the genetically deficient subjects therefore has served largely to increase our knowledge of the in-vivo role of complement. At the present time its clearest role is in...
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Developmental geneticists' contribution to the study of the evolution of morphological divergence has proceeded along two lines: comparative analysis of gene expression and quantitative genetics. Recent studies highlight how complementation tests between species can bridge the gap between these approaches.
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The complement system may be activated by at least two different pathways: the clinical pathway involving C1, C4 and C2 and the alternative pathway involving properdin, C3, factor B and factor D. The classical pathway can be activated by antigen antibody complexes, while the alternative pathway can be activated by other substances such as natural polysaccharides. Both pathways lead to an activ...
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The mammalian complement system plays an important role in the immune defense in blood and interstitial fluids. This set of ~30, mostly multi-domain, plasma proteins and cell-surface receptors enables the host to recognize and clear invading pathogens and altered host cells, while protecting healthy host cells and tissues. In addition to humoral immune defense, complement proteins are produced ...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 1975
ISSN: 1468-6244
DOI: 10.1136/jmg.12.4.372